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KMID : 0357920120460040331
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Korean Journal of Pathology
2012 Volume.46 No. 4 p.331 ~ p.340
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Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication
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You Tack-Kune
Kim Kyoung-Min
Noh Sang-Jae
Bae Jun-Sang
Jang Kyu-Yun
Chung Myoung-Ja
Moon Woo-Sung
Kang Myoung-Jae
Lee Dong-Geun
Park Ho-Sung
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Abstract
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Background: E-cadherin, cortactin, and matrix metalloproteinase (MMP)-9 have roles in tumor development or progression, but their expression has not been fully investigated in pseudoepitheliomatous hyperplasia (PEH) and squamous cell carcinoma (SCC) of the head and neck.
Methods: We evaluated the immunohistochemical expression of E-cadherin, cortactin, and MMP-9 in 29 cases of PEH and 97 cases of SCC. Additionally, we evaluated their relationship with clinicopathologic factors and prognostic implications in SCC.
Results: Thirty-five cases of SCC showed reduced expression of E-cadherin, whereas none of the PEH did. A total of 20 cases and 11 cases of SCC were immunoreactive for cortactin and MMP-9, respectively, whereas none of the PEH did. In SCC, reduced expression of E-cadherin was correlated with cortactin expression and invasion depth. Cortactin expression was correlated with differentiation, T classification, and recurrence and/or metastasis. MMP-9 expression was correlated with invasion depth. Cortactin expression was correlated with poor overall survival and relapse-free survival and it was an independent prognostic factor.
Conclusions: The reduced expression of E-cadherin and the expression of cortactin may be helpful for the differential diagnosis of PEH and SCC. Furthermore, cortactin expression in association with reduced E-cadherin expression is correlated with poor prognosis in SCC.
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KEYWORD
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Carcinoma, squamous cell, Pseudoepitheliomatous hyperplasia, Cadherins, Cortactin, Matrix metalloproteinase 9, Head and neck neoplasms
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